Sephure makes taking suppository medication... easier

Sephure is a disposable, single use suppository applicator that enables patients to quickly, hygienically and comfortably administer rectal suppositories. The applicator was designed by a Crohn’s patient and IBS sufferer to assist her struggle with taking prescribed suppository medication. Sephure has a unique patented technology that allows air to escape the body during the administration of medication and withdrawal of the device.

Suppositories can be administered using a Sephure applicator in any comfortable position, in less than five seconds. Sephure properly places the suppository within the body so the medication isn't felt and there is no struggle to keep the medicine in the body.


Patented Technology


       Sephure Applicators rely on Boyle’s Law of Physics to equalize the pressure inside and outside the body 

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Sephure Technology Offers Proper Placement of Suppositories Above the Anal-Rectal Line

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                               Benefits of Sephure


Patients Prefer Using Sephure Applicators to Finger Administration


Choosing to be compliant with your medication is a smarter way to a healthier life.

Sephure just makes it easier


"I was finding reasons to skip my suppository medicine because it was messy, cumbersome and took too much time out of my life. With Sephure, I can easily fit my medication treatment into my daily routine."

by Ryan, Patient, September 2014


Who Uses Sephure?

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Casey is a graduate student in addition to working part time and each day has a different schedule. Casey was prescribed suppository medication for treating internal hemorrhoids but the long administration times are difficult with a variable schedule.

Casey manages hemorrhoid flares using Sephure applicators to administer hemorrhoidal suppositories. This allows Casey to keep up with his busy, changing schedule and to treat hemorrhoids fast.


People with Hemorrhoids

About Hemorrhoids

Hemorrhoids are rectal vein inflammations affecting 40% of adults in the United States. 1 in 3 adults will develop chronic internal hemorrhoids in their lifetime. Pain from hemorrhoids can be difficult and both sitting and standing can cause discomfort.

Causes of Hemorrhoids

Straining to pass waste and sitting or standing for long periods can cause swelling of the veins in the rectal area. Hemorrhoids may also be caused by diarrhea, constipation, pregnancy, or weight gain.

Treatment of Hemorrhoids

The primary focus of treatment of hemorrhoids is to reduce the swelling, stress, and pressure on the veins. Doctors often suggest creams, ointments or suppositories prior to invasive medical procedures. Finger administration of suppositories can scratch or injure the rectal tissue and many patients prefer to use Sephure applicators for comfort and ease of administration.

People with IBS-C

About Irritable Bowel Syndrome with Constipation

Irritable bowel syndrome is a chronic functional bowel disorder, marked by changes in how the gastrointestinal tract works. While people with IBS experience frequent and unpredictable symptoms, there is no damage done to the bowel or the gastrointestinal tract. According to the National Institute of Health, 1 in 5 Americans live with Irritable Bowel Syndrome (IBS). Women are twice as likely to suffer from IBS.

Symptoms of Irritable Bowel Syndrome

Symptoms of IBS include abdominal pain or discomfort, bloating, cramping, diarrhea, constipation, or a combination of alternating bowel function. In fact, a symptom of constipation is diarrhea if there is incomplete evacuation of waste. Frequently, the person experiences abdominal pain and discomfort at least 3 times per month over a 3 month period that occur with a change in bowel habits.

Treatment of Irritable Bowel Syndrome

Doctors recommend increasing water intake and adding a soluble fiber supplement to one’s diet. Laxative suppositories offer rapid relief from symptoms without the stomach upset brought on by oral laxatives. Suppository medication is a first treatment for occasional IBS symptoms before more prescription medications are considered.

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Skyler works delivering packages in a high-stress environment where timing is critical. Finding time in the day to relax and take a break is nearly impossible, and food selections are often “on the go”.

Skyler used to take the occasional laxative suppository medication for treating IBS and constipation because it offered dependable and fast results. However she stopped taking them because the suppository wouldn’t always stay in the body, and re-administration was time-consuming and expensive.

Skyler now keeps Sephure applicators on hand for IBS flares because it’s a cleaner, more comfortable way to administer laxative suppository medication. With proper placement, her medication stays in the body offering the relief she needs quickly and easily.

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Taylor was involved in a severe motorcycle accident 7 years ago. Living with spinal cord injury has transformed Taylor’s everyday life, which now includes a daily bowel regimen.

Taylor requires laxative suppository medication for promoting daily bowel evacuation of waste but the ergonomics of self-administration and issues of hygiene make the daily process even more challenging.

With Sephure applicators, Taylor’s daily routine is easier and more comfortable.

People with Spinal Cord Injury

Spinal cord injury (SCI) is usually the result of a sudden injury or trauma. The damage interrupts the nerve signals between the brain that travel along the spinal cord to other parts of the body. According to the World Health Organization, there are nearly 1 million Americans living with spinal cord injury.

How Does SCI Affect the Gastrointestinal Tract?

It is common that the nerve communication to the gastrointestinal tract is damaged, preventing the proper elimination of waste. People with SCI often use laxative suppositories to stimulate the bowel.

Daily Bowel Regimen

Everyone’s body is different and timing your bowel regimen is similar to listening to the bodily signals in the past.  The important key is to establish a time of day (morning or night) and program interval (once a day, every other day, or every two days).  Following your program and timing in a consistent manner will reduce accidents and keep your body functioning well.  People with SCI can sometimes “train” their body to function in a rhythm similar to typical bowel habits triggered by bodily signals.

Emotional Consideration of SCI

Loss of bowel function, or dysfunctional bowel, can lead to emotional stress. Bowel training takes time and you’ll want to be relaxed and comfortable.  Be sure to plan enough time for complete evacuation and find a position that is easiest for you. Some people prefer to sit on a toilet seat while others prefer to lie on their left side. If you need help to complete your program, trust that caregivers will be understanding and caring of your human needs.

Why It's Important

Diarrhea or constipation can happen to people with SCI. Skipping or inconsistent timing of your program can lead to constipation and more severe, impacted bowel.  Not completing the bowel regimen by rushing, or not taking the time to completely evacuate the bowel, can lead to diarrhea.  Although safe when used occasionally, the regular using liquid enemas can irritate the bowel. Therefore, suppository medications are preferred by people with SCI for daily bowel regimen.  

People with Inflammatory Bowel Disease (IBD)

Inflammatory bowel diseases includes ulcerative colitis and Crohn’s Disease. Both are autoimmune diseases characterized by chronic inflammation of all or part of the digestive tract. The symptoms of IBD come and go with periods of remission marked with times of flare-ups when symptoms become pronounced and more extreme in severity. Inflammation affects the entire digestive tract in Crohn’s Disease and only the large intestine in ulcerative colitis.

IBD Facts

> IBD requires daily medications that Include suppositories to maintain remission

> IBD affects men and women equally

> 1.6 million people in the United States live with IBD

IBD Treatment

Treatment options for IBD patients are based on medical history, disease severity, and other factors. The best way to prevent advancement of the disease and minimize the risk of colorectal cancer is maintaining remission. Patients often use suppositories that offer targeted, personalized treatment for achieving and maintaining remission.

Without proper treatment and maintenance of remission, both forms of IBD can advance and may lead to hospitalization and surgery. The best way to maintain remission is to follow the treatment protocol prescribed by your doctor.

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Lea works in the legal profession in a job that requires long hours in addition to balancing a career and family. She finds suppository medication a burden.

Suppository medication was prescribed for treating Lea’s mild to moderate ulcerative proctitis, but the daily dosing interferes with her life and work.

Lea manages her remission of ulcerative proctitis with Canasa suppositories and uses Sephure applicators which allow fast administration without the need for protective undergarments.

People who use medical marijuana suppositories

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Effective Treatment for Today's Patients

Medical cannabis is an effective treatment option for a variety of conditions, including cancer, chronic pain, gastrointestinal disorders, anxiety, depression, and eating disorders. For some patients, however, the most popular methods of cannabis administration are not viable options. The other options for administration include pills, edibles, and topical treatments which do not always work well for patients. Pills can be difficult to swallow, edibles don’t always sit well with all patients, and sometimes topical treatments don’t deliver the level of treatment needed for a particular consumer.

29 states and the District of Columbia have laws legalizing medical marijuana. The prevalence of medical marijuana being prescribed by doctors continues to grow, and additional states are considering legalizing medical marijuana. This ever-expanding market is set to take off within the next five years as popularity in this treatment becomes a viable option for patients around the country.

Rectal cannabis in suppository form is an effective option for the majority of medical cannabis users. In addition to its long-lasting effects and simple administration, rectal cannabis is a great choice for people who need anxiety or pain relief without a foggy head.


Available in states with medical marijuana laws, specially compounded cannabis suppositories are used by patients with uncontrolled pain and nausea or appetite loss resulting from cancer and other medical treatments.

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Testimonial from a patient who uses Sephure with medical cannabis suppositories

“I am currently a patient in the Illinois Medical Cannabis pilot program for metastatic breast cancer. When I developed an ulcer and Barrett’s Esophagus during the summer of 2016, I needed to find an alternative method of delivery to bypass my stomach and esophagus. My dispensary recommended suppositories and sent me my first package of Sephure applicators. I also tried a competitor to see which ones I preferred. Sephure applicators are an exceptional product. It is not fun using suppositories but having attractive disposable applicators helps so much. I don’t think twice about using them anymore. I’ve been using them since late 2016.”
Susan G., Illinois

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Jamie’s mother is in the final stages of life after battling a long terminal illness. Wanting to assist with the in-home end-of-life care, Jamie is sometimes the only person to administer the suppository pain medications.

While a devoted and loving child, Jamie felt a sense of violation when administering suppository medication and the physical-ness of the process is an intrusion on the parent/child relationship.

Jamie found that Sephure applicators allowed a physical and emotional separation from the intimate experience of administering suppository medication.

People who Care for Others

Suppository medication is fast acting, efficient, and can be used to treat a patient systemically who has nausea or an inability to swallow. Bypassing the liver and the kidneys in the first pass of the metabolism, suppository medication is absorbed and delivered to the bloodstream quickly without traveling through the digestive system.

Fast acting medication minimizes the toxic effect to the liver and kidneys, and make suppository delivery well suited in managing pain and other symptoms for seriously ill and terminally ill patients. Additionally, patients who have limited mobility may require a daily bowel regimen that includes suppository laxatives.

The largest segment of population growth in the 20th century, known as the “baby boomers”, are aging. With that reality, many children of boomers will be faced with caring for their aging parents or by hiring a home healthcare taker. The advent of the home healthcare market brought institutional treatments into the home with hospice and palliative care.

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What Doctors and Nurses Think

Nurses and doctors prefer Sephure for administering suppositories because the applicator offers a barrier between the nurse and the patient while improving infection control. If you, or a loved one, require suppository medication, ask your healthcare professional or pharmacist about Sephure.

“In addition to the elimination of pain and embarrassment, I believe that Sephure will also assist in reducing infections and assist with the facility’s compliance with the federal health regulation, F Tag 441.”
– Long Term Care Nurse

"We trialed Sephure in our facility and got a lot of positive feedback from our nurses. Not only is this device more dignified for the patient, it’s more dignified for the nurse who has to give the suppository. This applicator ensures the suppository ends up in the right place, which means nurses don’t have to worry about them moving out of place before they can be effective. Great product!"

– Kayte M., RN, WNC

Try Sephure & Learn More

Why Healthcare Facilities Use Sephure Applicators

Nursing facilities have conducted value analyses of Sephure applicators and believe it to be a consistent standard of care that mitigates the risks of infection transfer and workplace injury.

The Number 1 workplace injury in hospital and nursing facilities is associated with moving a patient. With Sephure applicators, the suppository is properly placed, reducing the number of re-administrations and potential clean up from a misplaced suppository.

C-difficile is the leading healthcare facility-acquired infection.  C-diff spores are transferred to patients mainly from the hands of nurses who have touched a contaminated surface or device. Sephure applicators limit the nurse/patient contact.

According to an insurance risk assessor for LTC facilities in New England, adoption of Sephure mitigates risk of cross infection (C-difficile is the leading healthcare facility acquired infection) and workplace injury.

  • The savings of preventing one workplace injury is equal to a SIX year supply of Sephure. Avg cost for each workplace injury =$15,860.

  • The savings of preventing one C-difficile infection is equal to a NINE year supply of Sephure. Avg cost for each C-diff infection =$23,534.

I'd like to know more about trying Sephure applicators in our healthcare institution.
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